Migraine Medications and Treatment Options

Migraines are a complex set of disorders that cause throbbing, moderate-to-severe headaches that last from 4 to 72 hours.1,2 Unlike regular headaches, migraines have distinct phases that may include visual or sensory disturbances called auras.

Migraines are among the most common neurological disorders and more commonly affect women and younger people, although they can happen to anyone. The severe headaches of migraines can drastically affect daily life, causing physical, emotional, and financial pain.

Are Migraines Curable?

Unfortunately, there is no cure for migraines.1,3 However, there are many treatment options that may provide symptom relief and make your migraines less frequent and painful.

How Are Migraines Treated?

There are several different treatments available for those suffering from migraines.2-4 Treatments for migraine fall into one of two categories: acute or preventative.  Acute treatments are intended to provide immediate or fast-acting relief for migraine symptoms, depending on the medication. These therapies are generally taken either at the onset of a migraine headache or during the aura or prodrome phases.

In contrast, preventative treatments are intended to help prevent migraines, reduce their frequency, or make them less severe when they occur. Unlike acute treatments, preventative treatments must be taken regularly to work and do not provide relief if taken during a migraine headache.

Acute Therapies for Migraine

Anti-Inflammatory Drugs

Anti-inflammatory drugs are a broad class of drugs used for headaches, aches and pains, fevers, and migraines5. Non-steroidal anti-inflammatory drugs (NSAIDs) work by acting on molecules that trigger, worsen, or sustain inflammation, which can aggravate nerves that communicate pain signals to the brain. In migraines and other headaches, inflammation triggers pain signals in the head or amplifies them inside the brain6. By blocking or reducing inflammation, anti-inflammatory drugs can reduce the pain of headaches, including migraine headaches.

NSAIDs are the most commonly used drugs for migraines.5 However, they can have side effects for the gastrointestinal system and exacerbate bleeding, so not all patients can take them safely.

Anti-inflammatory drugs include:

  • Acetaminophen
  • Ibuprofen
  • Naproxen
  • Aspirin
  • Ketoprofen
  • Diclofenac
  • Tolfenamic acid
  • Piroxicam
  • Ketorolac


Triptans are a class of drugs primarily used to treat migraines that act by modifying the way the brain responds to serotonin. Serotonin is a chemical the brain uses to communicate between nerve cells and it affects how blood vessels in the brain open and close.7 Inappropriate electrical signals sweep over the brain during a migraine, partially regulated by serotonin. Triptans block molecules called receptors that react to serotonin, disrupting the process and providing pain relief.8 They are often combined with an NSAID to boost their effects.

Triptans include:

  • Naratriptan
  • Sumatriptan
  • Zolmitriptan
  • Eletriptan
  • Rizatriptan
  • Almotriptan
  • Frovatriptan


Nausea and vomiting are symptoms that occur during the headache phase of a migraine. Antiemetics are medications that treat nausea and vomiting.4 Antiemetics are given to patients alongside other drugs that target headache pain, most commonly an anti-inflammatory or a triptan.

Antiemetics include:

  • Metoclopramide
  • Prochlorperazine
  • Chlorpromazine


Much like triptans, lasmiditan helps treat migraine headaches by affecting serotonin in the brain.9 Unlike triptans, it does not affect blood vessels in the brain. This makes it especially useful for people with cardiovascular conditions or those who are at increased risk of stroke.


Ergots are a class of chemicals derived from a fungus that feeds on grain.10 Like other acute treatments for migraine, ergots target the serotonin system to provide quick-acting relief for headache pain. Ergots are commonly paired with caffeine for additional strength. Although ergots are effective, they are not as frequently prescribed as they were in the past, thanks to the development of newer triptans.

Ergots include:

  • Ergotamine
  • Dihydroergotamine

Preventative Treatments


Beta-blockers are a class of drugs often used to treat heart conditions and anxiety. They reduce the activity of the sympathetic nervous system, often called the “fight or flight” system.4 Beta-blockers are the first-line preventative treatment for migraines.11 It is not entirely understood how they help reduce the occurrence of migraines, but they are effective at reducing their length, intensity, and frequency.

Beta-blockers include:

  • Propranolol
  • Timolol
  • Atenolol
  • Nadolol
  • Bisoprolol


Most antidepressants act by affecting serotonin in the brain. As a result, they are also used to help reduce the occurrence and severity of migraines.4

Antidepressants include:

  • Amitriptyline
  • Fluoxetine


Anticonvulsants are drugs primarily used to treat epilepsy. They work by toning down the activity of nerves in the brain.4 Some anticonvulsants are used to effectively prevent migraines or reduce their frequency.

Anticonvulsants include:

  • Topiramate
  • Valproate

Calcium channel blockers

Calcium plays an important role in brain function. Calcium channel blockers affect the function of calcium in the brain, thereby affecting activity.4 These drugs are often prescribed for migraines in people who can get pregnant and people with Raynaud’s phenomenon, a circulatory condition affecting the extremities.

Anticonvulsants include:

  • Flunarizine
  • Verapamil

Calcitonin gene-related peptide antagonists:

Calcitonin gene-related peptide (CGRP) is a molecule that acts on the blood vessels in the brain, contributing to migraines.2-4 New antibody-based therapies can target this molecule and reduce the incidence of migraine episodes.

CGRP antagonists include:

  • Fremanezumab
  • Erenumab
  • Galcanezumab

Alternative Medicines

Many people seek non-pharmaceutical remedies for their migraine symptoms.12 These are often based on plant-derived compounds called phytochemicals that may affect how the brain and blood vessels work. In addition, nutrients like B vitamins are also frequently used as a remedy for migraines. Note that these substances are not approved by the FDA to treat migraine disorders and should be used in combination with medication.

Alternative medicines include:

  • Butterbur
  • Magnesium
  • Coenzyme Q10 (CoQ10)
  • B vitamins
  • Melatonin
  • Vitamin D
  • Ginger
  • Omega-3 fatty acids

Nontraditional Therapies

In addition to medication, migraines can be treated with neurostimulation.1 In these procedures, specific nerves or parts of the brain are activated or suppressed by electrical stimulation. This can have profound effects on migraine symptoms.

Neurostimulation techniques include:

  • Transcranial magnetic stimulation
  • Transcutaneous supraorbital nerve stimulation
  • Peripheral nerve blocking
  • Nonpainful remote electric neurostimulation

Living with Migraines

Although there are many effective treatments for migraines, medication is only one part of the picture.3 There are several lifestyle changes that can help you manage your migraines. The first step is understanding your triggers. Whether it’s bright lights, loud noises, or a particular smell, knowing your triggers lets you minimize your chances of encountering them and having a migraine episode.

Future of Migraine Treatments

Significant research is currently being performed to develop new therapies or adapt existing treatments for migraines. This includes drugs like botox, supplemental therapies like probiotics, new indications for existing antibody treatments like galcanezumab, and new neurostimulation techniques.13-16 With further development, these and other treatments could help bring better and longer-lasting relief for people with migraines.

Last updated: 07/25/2023Last medically reviewed: 07/05/2023

Medical Disclaimer: The information provided in this article is not a substitute for the advice of qualified healthcare professionals. While we strive to publish accurate information, it is not possible to cover all potential scenarios, including drug or treatment effects, interactions, or usage. You should not rely solely on this article to determine whether a particular treatment, drug, or clinical trial is suitable for you or any other individual. Always consult a healthcare professional before starting or changing any treatments.


  1. Pescador Ruschel MA, De Jesus O. Migraine headache. 2023, Treasure Island (FL): StatPearls Publishing: Statpearls [Internet].
  2. Shankar Kikkeri N, Nagalli S. Migraine with aura. 2023, Treasure Island (FL): StatPearls Publishing: Statpearls [Internet].
  3. Jenkins B. Migraine management. Aust Prescr, 2020. 43(5): p. 148-151.
  4. Lew C, and Punnapuzha S. Migraine medications, in StatPearls. 2023: Treasure Island (FL).
  5. Pardutz A and Schoenen J. NSAIDs in the Acute Treatment of Migraine: A Review of Clinical and Experimental Data. Pharmaceuticals (Basel), 2010. 3(6): p. 1966-1987.
  6. Kursun O, Yemisci M, van den Maagdenberg AMJM, and Karatas H. Migraine and neuroinflammation: the inflammasome perspective. J Headache Pain, 2021. 22(1): p. 55.
  7. Aggarwal M, Puri V, and Puri S. Serotonin and CGRP in migraine. Ann Neurosci, 2012. 19(2): p. 88-94.
  8. Cameron, C, Kelly S, Hsieh SC. Triptans in the acute treatment of migraine: a systematic review and network meta-analysis. Headache, 2015. 55 Suppl 4: p. 221-35.
  9. Goadsby, PJ, Wietecha LA, Dennehy EB. Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migraine. Brain, 2019. 142(7): p. 1894-1904.
  10. Ngo M, Tadi P. Ergotamine/Caffeine. 2023, Treasure Island (FL): StatPearls Publishing: StatPearls [Internet].
  11. Jackson JL, Kuriyama A, Kuwatsuka Y, et al. Beta-blockers for the prevention of headache in adults, a systematic review and meta-analysis. PLoS One, 2019. 14(3): p. e0212785.
  12. Wells RE, Beuthin J, and Granetzke L. Complementary and integrative medicine for episodic migraine: an update of evidence from the last 3 years. Curr Pain Headache Rep, 2019. 23(2): p. 10.
  13. Hoskin JL and Fife TD. New Anti-CGRP Medications in the treatment of vestibular migraine. Front Neurol, 2021. 12: p. 799002.
  14. Naghibi MM, Day R, Stone S, and Harper A. Probiotics for the prophylaxis of migraine: a systematic review of randomized placebo controlled trials. J Clin Med, 2019. 8(9).
  15. Becker WJ. Botulinum Toxin in the Treatment of Headache. Toxins (Basel), 2020. 12(12).
  16. Gibler RC, Knestrick KE, Reidy BL, Lax DN, and Powers SW. Management of chronic migraine in children and adolescents: Where are we in 2022? Pediatric Health Med Ther, 2022. 13: p. 309-323.